Structure-Biological Activity Relationship of Some Alkyl and Aryl Substituted Δ3 -Thiazolines

S. H. Elashry, A. I. Eissa*, R. S. Farag** and F. Z. Yehia

1Petrochemicals Dept., Egyptian Petroleum Research Institute, Nasr City, Cairo (Egypt)

²Faculty of Agriculture, Monofia University, Shebin El-Koom

³Faculty of Science, Al-Azhar University, Cairo (Egypt)

ABSTRACT:

The influence of different alkyl and aryl substituents in the available positions of Δ3- thiazoline ring, on the biological activity was investigated. Thus, 12 Δ3- thiazolines, with different alkyl or aryl substitutions were prepared by the reaction of elementary sulphur ammonia gas and ketones. Another three thiazolines, with different aryl substitutions in one position of the molecule, were prepared by the reaction of ∝ - mercapto pentanone-3, ammonia and aromatic aldhydes. The toxicities of the prepared compounds towards eleven species of bacteria and three species of Fungi and yeast* were screened. The minimum inhibitory concentrations (m. i. c) of the tested samples were determined in ∝ /ml. General relationships between the molecular structure and the biological activity of these compounds were outlined.

KEYWORDS:

Structure-Biological; Substituted

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Copy the following to cite this article: Elashry S. H, Eissa A. I, Farag R. S, Yehia F. Z. Structure-Biological Activity Relationship of Some Alkyl and Aryl Substituted Δ3 -Thiazolines. Orient J Chem 1989;5(1).

Copy the following to cite this URL: Elashry S. H, Eissa A. I, Farag R. S, Yehia F. Z. Structure-Biological Activity Relationship of Some Alkyl and Aryl Substituted Δ3 -Thiazolines. Orient J Chem 1989;5(1). Available from: http://www.orientjchem.org/?p=41349