Synthesis of New Indole Congeners as Promising Anti-Inflammatory Agents

Deepak Kumar¹, R. C. Agarwal¹ and Ashok kumar²*

¹Department of Chemistry, D.N. College, Meerut - 250 002 (India).

²Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M. Medical College, Meerut - 250 004 (India).

Substituted thiadiazolyl indoles and pyrazolyl indoles were synthesized as mentioned in scheme. Moreover these compounds also evaluated for their anti-inflammatory and analgesic activities. Compound 5e, i.e., N-(5-((lH-indol-3-yl)methyl)-l,3,4-thiadiazol-2-yl)-3-(2,4-dichlorophenyl) acryl amide and 6e, i.e. ,l-(3-((5-((lH-indol-3-yl)methyl)-l,3,4-thiadiazol-2-yl)-3-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone, were found to be most active compounds of this series, which exhibits 42.44 & 48.80% anti-inflammatory activity while, 40.13 & 44.64 % analgesic activity. The structures of all the newly synthesized compounds were characterized by analytical data, IR, 1H-NMR and Mass spectrometry.

Thiadiazolyl indole; Pyrazolyl indole; Anti-inflammatory and Analgesic Activities