ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of Fluorinated Pyrazolone Compounds

S. N. Thore* and Ashwini Kumar Gupta

Department of Chemistry, Vinayakrao Patil College, Vaijapure, Dist. Aurangabad (India).

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ABSTRACT:

Various fluorine containing (4Z)-2-(4-fluorophenyl)-4-[(1-phenyl-1H-pyrazol-4-yl)methylidene]-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one 3a-e, (4E)-2-(4-fluorophenyl)-4-[(4-oxo-3,4-dihydro-2H-chromen-3-yl)methylidene]-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one 5a-e and (4E)-4-[(2-chloroquinolin-3-yl)methylidene]-2-(4-fluorophenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one 7a-e have been synthesized. The compounds have been characterized by IR, 1H, NMR, MS study and further confirmed by elemental analysis.

KEYWORDS:

Fluorinated compound; 4-formyl pyrazole; 4-oxo 3-formyl chromene; 3-formyl Quinoline; Pyrazolone; anti-inflammatory; ant diabetic

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Thore S. N, Gupta A. K. Synthesis of Fluorinated Pyrazolone Compounds. Orient J Chem 2010;26(2).


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Thore S. N, Gupta A. K. Synthesis of Fluorinated Pyrazolone Compounds. Orient J Chem 2010;26(2). Available from: http://www.orientjchem.org/?p=24101



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