Synthesis and Antimicrobial Screening of Some Acid Chloride Derivatives of 2-Substituted Benzimidazoles

Sandeep Gupta¹*, S. S. Pancholi² and M. K. Gupta¹

¹Kota College of Pharmacy, Ranpur, Kota (India).

²S K Patel College of Pharmacy Education and Research, Ganpat University, Kherva (India).

ABSTRACT:

A large variety of 2-substituted benzimidazoles have been found to possess anti-inflammatory, antispasmodic, antihistaminic, antimicrobial, anticancer, cycloxygenase inhibitor, and HIV-1 reverse transcriptase inhibitor activities. 2-Alkyl benzimidazole and 2- aryl benzimidazoles were synthesized with different acids namely acetic acid, o-chlorobenzoic acid, benzoic acid and cinnamic acid. These were further treated with tosyl chloride and benzoyl chloride to get N-substituted benzimidazole derivatives. These N-substituted benzimidazoles were tested for antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Some of the products exhibited interesting activity with known standard drug at same concentration.

KEYWORDS:

Benzimidazoles; antibacterial activity; acid chloride

Download this article as: 

Copy the following to cite this article: Gupta S, Pancholi S. S, Gupta M. K. Synthesis and Antimicrobial Screening of Some Acid Chloride Derivatives of 2-Substituted Benzimidazoles. Orient J Chem 2009;25(1).

Copy the following to cite this URL: Gupta S, Pancholi S. S, Gupta M. K. Synthesis and Antimicrobial Screening of Some Acid Chloride Derivatives of 2-Substituted Benzimidazoles. Orient J Chem 2009;25(1). Available from: http://www.orientjchem.org/?p=23395