Synthesis and Biological Activity of N (Substituted) Benzylidine Ortho-Amino Benzoic Acid and N (Substituted) Benzyl Ortho-Amino Benzoic Acid

Kopal¹, Niranjan kaushik, Pankaj kumar, R. Hashim and Pradeep kumar²

¹Department of Pharmaceutical Analysis, PES College of Pharmacy, Bangalore India. ²College of Pharmacy, IFTM, Moradabad, India.

ABSTRACT:

A new series of N –(substituted) benzylidine and benzyl ortho – amino benzoic acids consisting of 12 compounds were synthesized. The use NaBH4 as a reducing agent for the reduction of N-(substituted) benzylidine ortho –amino benzoic acid to N- (substituted) benzyl ortho- amino benzoic acid appears to be new. The synthesized compounds were screened for their anti -inflammatory activity by carrageenan induced rat paw edema method. Some of these compounds have shown promising anti- inflammatory activity. ortho-amino benzoic acids are compounds with remarkable anti-inflammatory potential. These are a result of the application of classical medicinal chemistry bioisosteric drug design concepts since these derivatives are nitrogen isosteres of salicylic acid.

KEYWORDS:

N –(substituted) benzylidine; benzyl ortho – amino benzoic acid

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Copy the following to cite this article: Kopal K, kaushik N, kumar P, Hashim R, kumar P. Synthesis and Biological Activity of N (Substituted) Benzylidine Ortho-Amino Benzoic Acid and N (Substituted) Benzyl Ortho-Amino Benzoic Acid. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Kopal K, kaushik N, kumar P, Hashim R, kumar P. Synthesis and Biological Activity of N (Substituted) Benzylidine Ortho-Amino Benzoic Acid and N (Substituted) Benzyl Ortho-Amino Benzoic Acid. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=24148