Synthesis of 7-Substituted-2-(Arylidene)-6 Fluoro-(1,3) Benzothiazole for Anti-Tumor Activity.

Shantharam U; Rajesh Antony; Shachindra. L. N; D.S. Puranik; L. V. G. Nargund; Vasudev Nayak

Article | Open Access

Synthesis of 7-Substituted-2-(Arylidene)-6 Fluoro-(1,3) Benzothiazole for Anti-Tumor Activity.

Shantharam U¹, Rajesh Antony¹, Shachindra.L. N², D.S. Puranik¹ , L. V. G. Nargund¹ and Vasudev Nayak²

¹Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, B.S.K. III Stage, Bangalore - 85 (India) ²Department of Pharmaceutical Chemistry, Kuvempu University, Shimoga, Karnataka (India)

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ABSTRACT:

4-fluoro-3-chloroaniline treated with potassiumthiocyanate in presence of acetic acid and bromine were converted into 2-amino-6-fluoro-7-chloro (1,3) benzothiazole which was further treated with Benzaldehyde in presence of ethanol and HCl results (substituted benzyl)-6-fluoro-7-chloro- (1,3)-benzothiazole. The above said compounds refluxed for two hours with equimolar quantities of various substituted amines in the presence of dimethylformamide to obtain different respective substituted Benzothiazolo-aryledene derivatives. Some of the compounds have promising anti-tumor activity.

KEYWORDS:

Benzothiazole; anti-tumor activity