Synthesis and Anti-Microbial Activity of Pyrano [2,3-C] Pyrazole Derivatives

Hitesh D. Patel*, B. D. Mistry** and K. R. Desai***

¹Department of Chemistry, South Gujarat University, Surat- 295 001 (India) ²Department of Chemistry, B.K.M. Science College, Valsad- 396 001 (India) ³Department of Chemistry, St. Xavier's College, Ahmedabad- 380 009 (India)

Various pyrano[2,3-C] pyrazole derivatives [I(a-k)] were prepared from 1-(3'-chloro phenyl)-3-methyl-5-pyrazolone. Reaction between 1-(3'-chloro phenyl)-3-methyl-5-pyrazolone, malanonitrile and various aldehydes in presence of piperidine in ethanol gave pyrano [2,3-C] pyrazole derivatives [I(a-k)]. These compounds were characterized on the basis of elemental and spectral analysis. All the newly synthesized compounds were tested for their antimicrobial activity.

Pyrazole derivatives; Antimicrobial activity