A Decade of Development of Ethylidenethiosemicarbazides as Building Blocks for Synthesis of Azoles and Azines ( A Review )

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However, reaction of two moles of ethyl bromoethanoate with one mole of compound 5 g a v eN -e t h o x y c a r b o n y l t h i a z o l e -5 ( 4H ) -o n e derivative 6,53,78 42, which was obtained from treatment of 40 with 41 (Scheme 19).

Antiviral activity
Ethylidenethiosemicarbazide with aryl or benzimidazole substituents were evaluated as antiviral agents and showed moderate activity in most cases 5,33,107,108 (Chart 2).

Anticonvulsant activity
Thiosemicarbazones are promising anticonvulsant candidates 8 that contain non-polar groups(aryl or heteroaryl) and thiourea residue (polar group which is responsible for hydrogen bonding) (Chart 4).

Antiparasitic activity
Recent research focuses on developing new drugs for Chagas diseases, caused by the protozoan parasite Trypanosoma Cruzi.

Chart 6 .
Miscellaneous activities of Ethylidenethiosemicarbazide