Abstract

Amri Setyawati¹, Indriana Kartini², Deni Pranowo² Dan Lisna Junaeni Muiz³  and Syafitri Hasyati²

DOI : http://dx.doi.org/10.13005/ojc/330637

Currently, wound dressing is made of fabric or polyvinyl chloride (PVC) plastics with silver as active ingredients. Residues of silver can be toxic in the environment and PVC waste is a very long decomposed by soil. Chitosan and carboxymethyl chitosan (CMC) film have been synthesized as a biodegradable material that potential to replace silver wound plasters. CMC film has been synthesized from chitosan with a wide range of molecular weight. Chitosan with high molecular weight resulting from the reflux (1a) while the low molecular weight chitosan produced from microwaves assisted organic synthesis-MAOS (1b). All chitosan and CMC are then molded into a film chitosan and CMC and their properties were analyzed by solubility test. The COOH number of the CMC is also measured by titration. The results show that the CMC were synthesized from chitosan MAOS (2b) has higher COOH group than CMC from chitosan reflux (2a). Chitosan with MAOS process is able to produce a more homogeneous and has a lower molecular weight in a short time. Chitosan 1a films are strong and rigid while chitosan films 1b and CMC films have fragile nature. Test of solubility in physiological solution showed that the CMC films lost 78.56% Massa while chitosan films 1a only 44.59%. This show that a combination of chitosan films for wound plaster with CMC films as a wound healer active ingredient is suitable for replacing the fabric wound plasters contains silver as an active ingredient.

chitosan; carboxymethyl chitosan; film; wound healer

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