Abstract

Muayed Ahmed Redayan¹, Wassan Baqir Ali² and Ahmed Mudhafar Mohammed²

DOI : http://dx.doi.org/10.13005/ojc/330656

A series of novel 5-amino-1,3,4-thiadiazole-2-thiol and 1,3,4-thiadiazole-2,5-dithiol  derivatives of benzimidazole were synthesized through nucleophilic substitution reaction of 5-substituted-2-(chloromethyl)-1H-benzimidazole, structures of the synthesized compounds were proved by spectral methods of analysis ( FT-IR, ¹H and ¹³C NMR ). All the target compounds were screened for their antibacterial activity toward  gram-negative (E.coli, P. aeruginosa) and gram-positive (B. subtilis, S. aureus) bacteria, most of the synthesized derivatives  exhibited good to moderate  activity toward both  gram-positive (B. subtilis, S. aureus) and gram-negative (E.coli, P. aeruginosa) bacteria.

Benzimidazole; Bis Benzimidazole; 1,3,4-Thiadiazole; Antibacterial Activity

[ View HTML Full Text]