Abstract

Mohammad Mahdi Saadatmand¹, Mohammad Esmail Yazdanshenas¹, Ramin Khajavi², Fariba Mighani³ and Tayebeh Toliyat⁴

DOI : http://dx.doi.org/10.13005/ojc/330527

In this study, it was aimed to present a nanofibrous scaffold with intentional roughness through a new electrospinning method called “mesh electrospinning method”. Firstly, polyamide nylon 6 granules were dissolved in formic acid in different concentration (10-35%w/v). A mesh template was placed between tip and collector in different distance (4 positions) in a conventional electrospinning line. The number of mesh layers and effects of processing parameters also considered. As it was expected, the results show that, increasing the polymer solution lead to increase fiber diameter, from 84nm for 20% to 265nm for 30%. The results showed that the layer just formed when the mesh was placed just on the collector. On the other hand, with increasing the number of mesh layers (1&3), roughness decreased (55-60%).  It was also observed that the produced roughness is governed by the geometry of the mesh. To consider the ability for controlling the roughness, the produced roughness can be applied for drug delivery purposes transdermal drug delivery.

Electrospinning; Roughness; Mesh; Polyamide; Nanofiber

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