Abstract

Khawla M. Sultan Al-Juboori

DOI : http://dx.doi.org/10.13005/ojc/330524

A range of mixed ligand complexes derived from the reaction of alanine (alan), glycine (gly) and isoniazid (ison) ligands with Cr⁺³, Co⁺², Cu⁺², Fe⁺³, and Ni⁺² ions are reported. Complexes were characterized using a variety of techniques that include; FTIR, UV-Vis., HPLC, TGA, elemental analyses, chloride content, magnetic susceptibility, melting point and conductivity. The obtained results indicated the formation of complexes in a 1:1:1:1mole ratio of M:alan:gly:ison with the general formula [M(Gly)(Alan)(Ison)(H₂O)_nCl_w]Y (M = Cr⁺³, w = 2, n = 1, Y = Cl; Fe⁺³_,w = 0, n = 3, Y = 3(NO₃^-); Co⁺², w = 1, n = 2, Y = Cl; Cu⁺², w = 0, n = 3, Y = 2(NO₃^-) and Ni⁺² , w = 0, n = 3, Y = 2Cl).The analyses data indicated distorted octahedral geometries about metal centres. The bio-assay of the prepared complexes show a positive activity against normal tuberculosis bacteria. However, the complexes exhibit no activity against the resistance tuberculosis bacteria.

Mixed ligand complexes; Isoniazid; Amino acids; Preparation and characterisation;; Anti-tuberculosis assay

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