Abstract

Govindaraj Chinnasamy¹, Kullagounder Subramani² and Venkatesan Srinivasan³

DOI : http://dx.doi.org/10.13005/ojc/330430

One pot synthesis of Naphtaleno-4,6-(2,4-quinoxaline) derivatives were achieved usingdirect coupling reaction by retaining 2,3-diaminonaphthalene as common with different forms of diketones viz., Benzil, 4, 4'-dimethyl Benzil and 4, 4'-difluoro Benzil. The synthesis was carried out using CTAB and polymer supported sulphanilic acid, independently. The use of 4,4'-difluoro Benzil was found to be better than 4,4'-dimethyl Benzils, in terms of the % yield and the time consumption. Results confirmed that the use of CTAB was superior to the sulphanilic acid in the majority of aspects. Quinoxaline derivatives, so obtained, were independently used for the biological study to determine their efficiency in mice foranxiolytic, sedative and hypnotic activity. It was learned from the results that the Naphtaleno-4,6-(2,4-quinoxaline) derivatives were far better than their standard Diazepam in sedative and hypnotic activity. However, the efficiency was comparatively lesser than Diazepam in anxiolytic activity. In most cases, Fluoro substituted Diazepine show deviation in activity. The results oflocomotor activity suggest the appreciable alertness of the mice when exposed to naphthalene based quinoxaline drugs.

Quinoxaline derivatives; CTAB; sulphanilic acid; anxiolytic; sedative; hypnotic

[ View HTML Full Text]