Abstract

Annissa^1,2, Tati Suhartati¹, Yandri¹ and Sutopo Hadi¹

DOI : http://dx.doi.org/10.13005/ojc/330310

In this paper, we reported the syntheses and antibacterial activity test of 2 organotin(IV) compounds, diphenyltin(IV) di-3-chlorobenzoate (2) and triphenyltin(IV) 3-chlorobenzoate (4). These two compounds were prepared by the reaction of diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide with 3-chlorobenzoic acid. These compounds were  characterized by ¹H and ¹³C NMR, IR, UV-Vis spectroscopies and also based on the microanalytical data.  The results of antibacterial activity by diffusion method against Pseudomonas aeruginosa and Bacillus subtilis showed that the triphenyltin(IV) 3-chlorobenzoate was active at concentration of 3.956 x 10^-4 M (200 ppm), while the chloramphenicol gave inhibition of 6.1894 x 10^-4 M (200 ppm), although the halozone was bigger. This result indicated that compound 4 is potentially to be used as antibacterial substance, although the search of other derivative of organotin(IV) with other ligands is still needed to get much higher and much better activity.

Antibacteria; B. subtilis; organotin(IV) 3-chlorobenzoate; P. aeruginosa

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