Abstract

A. Parameshwar¹, V. Selvam², Majid Ghashang³ and S. Guhanathan⁴

DOI : http://dx.doi.org/10.13005/ojc/330355

Heterocyclic compounds containing the five-membered oxadiazole nucleus possess verity of biological activities. 1,3,4- oxadiazole moieties are important because of their versatile biological action. The present study depicts synthesis of some novel 2-(2-(cyclopropylmethoxy)phenyl)-5-methyl-1,3,4- oxadiazole was prepared from N'-acetyl-2-(cyclopropylmethoxy)benzohydrazide by using triphenylphosphine, triethylamine, carbon tetrachloride and acetonitrile at 100°C for 1h. The final compound was examined for its antibacterial activity.

Antibacterial activity; (bromomethyl)cyclopropane; gentamicin; hydrazine monohydrate; triphenylphosphine

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