ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation

Radia Bouasla1,2, Khaoula Bechlem1, Billel Belhani1, Ismahene Grib1, Nour-Eddine Aouf1 and Malika Berredjem1

DOI : http://dx.doi.org/10.13005/ojc/330348


Abstract:

A facile and versatile method for acylation of structurally diverse amines and sulfonamides under focused ultrasonic irradiation in catalyst-free and solvent-free conditions is reported. There are several advantages to this approach such as simple and easier workup conditions, small amount of time and high yielding. The acylation reaction was carried out with acetic anhydride. All structures of synthesized products have been identified by NMR and mass spectroscopy.

Keywords:

N-acylation; sulfonamide; ultrasonic irradiation; acetic anhydride; green chemistry

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