Abstract

Ravi Kumar G. M. V. N. A. R. and Arumugam Thangamani

DOI : http://dx.doi.org/10.13005/ojc/330361

A series of six novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives have been synthesized starting from commercially available substituted acetophenones via OxoketeneDithioacetals with high yields. Ketene dithioacetals to react with 2-aminoethanol or l-amino-2-propanol to afford the corresponding substituted 2-methyleneoxazolidines which are utilized in the synthesis of 6-aryl-2-amino-4-pyrimidinamine Derivatives. The molecular docking studies revealed that all the synthesized compounds best fit into the active site of HDAC2, anti-cancer protein.

2-amino-pyrimidine Derivatives; Ketene dithioacetals; Cyclic Ketene N; O-acetal; Molecular docking

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