Abstract

Afinisha Deepam and  Jyothi Viswanadhan

DOI : http://dx.doi.org/10.13005/ojc/330336

Environment-friendly, facile, cost effective green chemical methods are reported for the one-pot multicomponent solvent less synthesis of 1-aminoalkyl-2-naphthol and 1-amidoalkyl-2-naphthol exploring tannic acid as a novel, biodegradable, cheap and efficient Lewis acid catalyst. Present investigation focuses on green chemistry approach for the synthesis of aminoalkyl and amidoalkyl compounds.  A mixture of sufficient amount of tannic acid, vanillin, 2-naphthol and 4-nitroaniline/ benzamide is refluxed by following various green protocols such as oil bath, microwave irradiation, hot plate with magnetic stirrer, Grindstone method and finally conventional heating method. Structure of the products confirmed by spectroscopic techniques such as IR, ¹H NMR, ¹³C NMR and GC-MS. Anti-bacterial activity of synthesized compounds against Bacillus subtilis is tested by zone inhibition method.

Amidoalkyl naphthol; Aminoalkyl naphthol; microwave synthesis; Grindstone chemistry; Oil bath; Vanillin; 2-naphthol

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