Abstract

Bhoopathy Parasuraman, Jayalakshmi Rajendran and Rajavel Rangappan

DOI : http://dx.doi.org/10.13005/ojc/330321

Mononuclear complex has been used as a building block in the synthesis of homo/hetero binuclear complexes. The complex behaves as a potential metallo-ligand. Its reaction with different metal salts (Ni & Cu) lead to the formation of binuclear complexes. The homo and hetero binuclear oxygen bridged Cu(II) and Ni(II) complexes had been synthesized from the Schiff base ligand derived from 4-chloro-o-phenylenediamine  and 3,5-dichloro-2-hydroxyacetophenone. The synthesized complexes have been characterized with the support of more than a few standard physicochemical techniques such as elemental analysis, spectroscopic, thermal, cyclic voltammetry and magnetic moment studies. Spectral analysis exhibits square planer geometry for Cu(II) & Ni(II) mono and binuclear complexes. The antimicrobial results indicate that the homo-binuclear copper complex exhibit more activity than the other mono and binuclear complexes. The Schiff base and their complexes have been screened for their anticancer activity using MCF7 cell line.

4-chloro-o-phenylenediamine; thermal; antibacterial; MCF7; square planar

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