Abstract

Maryam Derakhshandeh and Majid Monajjemi

DOI : http://dx.doi.org/10.13005/ojc/330214

Ampicillin, Clavulanic acid, Imipenem, Penicillin G and Ticarcillin properties for the drug delivery in viewpoint of NMR shielding and S-NICS investigation have been studied. Phenoxy-acetic acid for Penicillin V or Penicillin and its alteration Penicillin G are used for large scale production. Various Penicillins and the other cells-wall inhibitor are mainly specific against gram(+) bacteria due to highest percentage of peptidoglycan” in the cells-wall of those organisms. Ampicillin which is belongs to the penicillin groups of beta lactam-antibiotics is capable to penetrate gram(+) and some gram(-) bacteria. Imipenem or Primaxine is an intravenous-β-lactam antibiotic discovered by William Leanza, Kenneth Wildonger and Burton Christensen from Merck scientists in 1980. It was the first part of the carbapenem kinds of antibiotics. Based on our previous works⁸² we have design and simulated a drug delivery system of those antibiotics. In this study, we have discussed a statistical approach via computing of nucleus-independent chemical shifts (S-NICS) in view point of probes motions in a sphere of de-shielding and shielding spaces of antibiotic rings. In the related work⁸², it has been exhibited that S-NICS method is a suitable method for evaluting the aromaticity in the non-benzene rings such as those antibiotics which are important compounds for organic chemical synthesize and reactions.

Ampicillin; Clavulanic acid; Imipenem; Penicillin G; Ticarcillin; NMR and S-NICS

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