Abstract

Mahshid Aslani¹, Masoumeh Meskinfam² and  Hamid Reza Aghabozorg³

DOI : http://dx.doi.org/10.13005/ojc/330127

Inorganic-polymeric composites are promising materials for bone repair; the so called biomimetic approach leverages the interaction between polymer and inorganic mineral and generates the appropriate material features. In this work, gelatin ‒ multiwalled carbon nanotube (MWCNT) – hydroxyapatite (HA) biocomposites containing different concentration of gelatin were prepared by in situ biomimetic approach. The synthesized composites were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The results showed that, gelatin is a suitable matrix for nucleation and growth of hydroxyapatite nanocrystals and homogenous dispersion of nanotubes. Mesenchymal Stem cells (MSCS) culturing on composites and MTT assays were used to determine the in-vitro biocompatibility of the synthetized biocomposides, which showed no negative effect on the cell viability and proliferation. The experimental work has demonstrated that increasing gelatin concentration can lead to the formation of more uniform HA spherical particles and enhance the biocompatibility of the composites. 

Gelatin; Biocompatibility; Hydroxyapatite; bone filler

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