Abstract

Namala Rambabu*^1,3, Bhavani Ram³,Pramod Kumar Dubey¹, Bhavani Vasudha² and Bhavani Balram³

DOI : http://dx.doi.org/10.13005/ojc/330126

The hydrazide-hydrazone analogs 4a-4l is described via the condensation of3,4,5-trimethoxybenzohydrazide 3 with various aromatic and hetero aromatic aldehydes a-l. Various spectroscopic techniques viz., (¹H NMR, ¹³C NMR, IR and MS) were utilized to determine the structures of synthesized compounds. These compounds were evaluated for antibacterial, antifungal screening against S.aureus, S.pyogenes, E.coli, P.aeruginosa, Aspergillusnigerand Candida albicans(Fungal strains). The results revealed that most of the hydrazone derivatives exhibited significant antibacterial activity. Furthermore, the synthesized hydrazone derivatives were found to exhibit significant antidiabetic activity when compared to insulin.

Eudesmic acid; Hydrazones; Gallic acid; Antibacterial activity; Synthesis

[ View HTML Full Text]