Abstract

L. Siva Sanker Reddy *,T. Rajkumar, G. Lakshmi Mrudula and Y. Siva Rami Reddy

DOI : http://dx.doi.org/10.13005/ojc/31.Special-Issue1.23

Pyrazolines display a broad spectrum of potential pharmacological activities. Hence pyrazolines are used extensively as useful synthons in organic synthesis.  4-Amino  acetophenone was  diazotized  then  followed  by  coupling with morpholine  as  a means  of  protection  of    amine  group  in  4-Amino  acetophenone. The obtained product is then made to react with different aldehydes in the presence of 40% KOH solution as catalyst to yield chalconederivatives. These are then subjected for cyclization by treating with hydrazine hydrate.  The structures were proposed based on ¹H NMR and IR spectral data. All the compounds are screened for Anti-oxidant and anti Inflammatory activity.  

Chalcones; 4-Amino acetophenone; Pyrazolines; Anti-oxidant; Anti- Inflammatory

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