Abstract

Suheb Saleh¹, Usama Al-Timari², Aeed Al-Fahdawi³, Naseem El-Khatatneh⁴, Chandra⁵, Mahendra M⁴ and Mohammed Al-Ghorbani⁶

DOI : http://dx.doi.org/10.13005/ojc/330604

A new series of substituted quinoline and pyridine derivatives 6a-h are synthesized by the coupling of hydrazide derivatives 4a-b with substituted carboxylic acids 5a-c in the presence of TBTU as a coupling agent and lutidine as a base. The newly synthesized compounds 6a–l is characterized by analytical NMR and mass spectral data. The newly synthesized compounds are subjected to molecular docking studies for the inhibition of human Aurora A kinase target to evaluate their potential value for the treatment of cancers.

Synthesized Compounds; Substituted; Molecula

[ View HTML Full Text]