ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Synthesis, Characterization and Molecular Docking of Novel Quinoline and Pyridine Derivatives

Suheb Saleh1, Usama Al-Timari2, Aeed Al-Fahdawi3, Naseem El-Khatatneh4, Chandra5, Mahendra M4 and Mohammed Al-Ghorbani6

DOI : http://dx.doi.org/10.13005/ojc/330604


Abstract:

A new series of substituted quinoline and pyridine derivatives 6a-h are synthesized by the coupling of hydrazide derivatives 4a-b with substituted carboxylic acids 5a-c in the presence of TBTU as a coupling agent and lutidine as a base. The newly synthesized compounds 6a–l is characterized by analytical NMR and mass spectral data. The newly synthesized compounds are subjected to molecular docking studies for the inhibition of human Aurora A kinase target to evaluate their potential value for the treatment of cancers.

Keywords:

Synthesized Compounds; Substituted; Molecula

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